| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Pregnancy, fertility concerns and fertility preservation procedures in a national study of French breast cancer survivors |
| Creator | Mangiardi-Veltin et al. |
| Author | Manon Mangiardi-Veltin |
| Author | Clara Sebbag |
| Author | Christine Rousset-Jablonski |
| Author | Isabelle Ray-Coquard |
| Author | Clémentine Berkach |
| Author | Lucie Laot |
| Author | Yuting Wang |
| Author | Inès Abdennebi |
| Author | Julie Labrosse |
| Author | Camille Sautter |
| Author | Aullène Toussaint |
| Author | Laura Sablone |
| Author | Enora Laas |
| Author | Sarah Khallouch |
| Author | Florence Coussy |
| Author | Pietro Santulli |
| Author | Charles Chapron |
| Author | Angelique Bobrie |
| Author | William Jacot |
| Author | Nadir Sella |
| Author | Elise Dumas |
| Author | Claire Sénéchal-Davin |
| Author | Marc Espie |
| Author | Sylvie Giacchetti |
| Author | Lorraine Maitrot |
| Author | Geneviève Plu-Bureau |
| Author | Charles Coutant |
| Author | Julien Guerin |
| Author | Bernard Asselain |
| Author | Pierre Fumoleau |
| Author | Manuel Rodrigues |
| Author | Christine Decanter |
| Author | Audrey Mailliez |
| Author | Lidia Delrieu |
| Author | Amélie Lemoine |
| Author | Christelle Jouannaud |
| Author | Doriane Houdre |
| Author | Fabien Reyal |
| Author | Anne-Sophie Hamy |
| Abstract | RESEARCH QUESTION: What are the real-life oncofertility practices in young women diagnosed with breast cancer? DESIGN: The FEERIC (FErtility, prEgnancy, contRaceptIon after breast Cancer in France) study is a web-based cohort study launched with the French collaborative research platform Seintinelles. The current work is based on the enrolment self-administered questionnaire of 517 patients with prior breast cancer diagnosis, free from relapse and aged 18 to 43 years at inclusion (from 12 March 2018 to 27 June 2019). RESULTS: Median age at breast cancer diagnosis was 33.6 years and 424 patients (82.0%) received chemotherapy. Overall, 236 (45.6%) patients were offered specialized oncofertility counselling, 181 patients underwent at least one fertility preservation procedure (FPP); 125 (24.2%) underwent one or more FPP with material preservation (oocytes n = 108, 20.9%; embryos n = 31, 6.0%; ovarian cryopreservation n = 6, 1.2%) and 78 patients received gonadotrophin-releasing hormone agonists (15.1%). With a median follow-up of 26.9 months after the end of treatments, 133 pregnancies had occurred in 85 patients (16.4%), including 20 unplanned pregnancies (15.0%). Most of the pregnancies were natural conceptions (n = 113, 87.6%), while 16 (12.4%) required medical interventions. For the planned pregnancies, median time to the occurrence of an ongoing pregnancy was 3 months. Patients who had an unplanned pregnancy reported lower rates of information on the consequences of the treatments on fertility (P = 0.036) at diagnosis. CONCLUSIONS: Most of the patients were not offered proper specialized oncofertility counselling at the time of breast cancer diagnosis. Naturally conceived pregnancies after breast cancer were much more frequent than pregnancies resulting from the use of cryopreserved gametes. Adequate contraceptive counselling seems as important as information about fertility and might prevent unplanned pregnancies. |
| Publication | Reproductive Biomedicine Online |
| Volume | 44 |
| Issue | 6 |
| Pages | 1031-1044 |
| Date | 2022-06 |
| Journal Abbr | Reprod Biomed Online |
| Language | eng |
| DOI | 10.1016/j.rbmo.2021.12.019 |
| ISSN | 1472-6491 |
| Library Catalog | PubMed |
| Extra | PMID: 35525718 |
| Tags | Breast Neoplasms, Cohort Studies, Contraception, Cryopreservation, Female, Fertility Preservation, Humans, marque, Neoplasm Recurrence, Local, original, Pregnancy |
| Date Added | 2022/07/29 - 11:34:57 |
| Date Modified | 2022/08/01 - 14:02:43 |
| Notes and Attachments | PubMed entry (Attachment) Version soumise (Attachment) |
Institut de Recherche en Cancérologie de
