| Added by | Nathalie Bonnefoy |
|---|---|
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils |
| Creator | Engblom et al. |
| Author | Camilla Engblom |
| Author | Christina Pfirschke |
| Author | Rapolas Zilionis |
| Author | Janaina Da Silva Martins |
| Author | Stijn A. Bos |
| Author | Gabriel Courties |
| Author | Steffen Rickelt |
| Author | Nicolas Severe |
| Author | Ninib Baryawno |
| Author | Julien Faget |
| Author | Virginia Savova |
| Author | David Zemmour |
| Author | Jaclyn Kline |
| Author | Marie Siwicki |
| Author | Christopher Garris |
| Author | Ferdinando Pucci |
| Author | Hsin-Wei Liao |
| Author | Yi-Jang Lin |
| Author | Andita Newton |
| Author | Omar K. Yaghi |
| Author | Yoshiko Iwamoto |
| Author | Benoit Tricot |
| Author | Gregory R. Wojtkiewicz |
| Author | Matthias Nahrendorf |
| Author | Virna Cortez-Retamozo |
| Author | Etienne Meylan |
| Author | Richard O. Hynes |
| Author | Marie Demay |
| Author | Allon Klein |
| Author | Miriam A. Bredella |
| Author | David T. Scadden |
| Author | Ralph Weissleder |
| Author | Mikael J. Pittet |
| Abstract | Bone marrow-derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively investigated, but the contribution of the systemic host environment to tumor growth remains poorly understood. Here, we show in mice and cancer patients (n = 70) that lung adenocarcinomas increase bone stromal activity in the absence of bone metastasis. Animal studies reveal that the cancer-induced bone phenotype involves bone-resident osteocalcin-expressing (Ocn+) osteoblastic cells. These cells promote cancer by remotely supplying a distinct subset of tumor-infiltrating SiglecFhigh neutrophils, which exhibit cancer-promoting properties. Experimentally reducing Ocn+ cell numbers suppresses the neutrophil response and lung tumor outgrowth. These observations posit osteoblasts as remote regulators of lung cancer and identify SiglecFhigh neutrophils as myeloid cell effectors of the osteoblast-driven protumoral response. |
| Publication | Science (New York, N.Y.) |
| Volume | 358 |
| Issue | 6367 |
| Date | 12 01, 2017 |
| Journal Abbr | Science |
| Language | eng |
| DOI | 10.1126/science.aal5081 |
| ISSN | 1095-9203 |
| Library Catalog | PubMed |
| Extra | PMID: 29191879 PMCID: PMC6343476 |
| Tags | Adenocarcinoma, Adenocarcinoma of Lung, Animals, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Bone and Bones, Bone Density, Bone Marrow Cells, Cell Line, Tumor, Humans, Lectins, Lung Neoplasms, Mice, Mice, Inbred C57BL, Myeloid Cells, Neoplasms, Experimental, Neutrophil Infiltration, Neutrophils, original, Osteoblasts, Osteocalcin, Receptor for Advanced Glycation End Products |
| Date Added | 2019/05/28 - 21:18:42 |
| Date Modified | 2019/05/28 - 21:18:55 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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