| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Optimal First-Line Medico-Surgical Strategy in Ovarian Cancers: Are We There Yet? |
| Creator | Quesada et al. |
| Author | Stanislas Quesada |
| Author | Quentin Dominique Thomas |
| Author | Pierre-Emmanuel Colombo |
| Author | Frederic Fiteni |
| Abstract | In spite of tremendous advances in advanced ovarian cancer management through the past decade, notably owing to surgical expertise and novel combination molecules (including bevacizumab and PARP inhibitors), the optimal initial sequential strategy remains a major concern. Indeed, following seminal clinical trials, primary cytoreductive surgery (PCS) followed by adjuvant systemic therapy and interval cytoreductive surgery (ICS) following neoadjuvant chemotherapy (NACT) have been positioned as validated alternatives with distinct pros and cons, although a definite response is still unassessed. In clinical practice, decisions between PCS and ICS rely on multilayer parameters: the tumor itself, the patient, and the health structure. In this state-of-the-art review, we will discuss the current evidence based on clinical trials and real-world data and highlight the remaining questions, including the fittest positioning of PCS vs. ICS and the optimal number of NACT cycles; subsequently, we will discuss current axes of research such as dedicated clinical trials and more global perspectives. These ongoing strategies and perspectives could contribute to improving the patient journey through personalized medicine. |
| Publication | Cancers |
| Volume | 15 |
| Issue | 14 |
| Pages | 3556 |
| Date | 2023-07-10 |
| Journal Abbr | Cancers (Basel) |
| Language | eng |
| DOI | 10.3390/cancers15143556 |
| ISSN | 2072-6694 |
| Short Title | Optimal First-Line Medico-Surgical Strategy in Ovarian Cancers |
| Library Catalog | PubMed |
| Extra | PMID: 37509219 PMCID: PMC10377152 |
| Tags | clinic, interval cytoreductive surgery, medicosurgical strategy, primary cytoreductive surgery |
| Date Added | 2023/10/16 - 14:55:29 |
| Date Modified | 2023/10/16 - 17:27:41 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
