| Added by | standudu |
|---|---|
| Last modified by | liaudet-coopman |
| Group name | EquipeELC |
| Item Type | Journal Article |
| Title | Tenascin-X: beyond the architectural function |
| Creator | Valcourt et al. |
| Author | Ulrich Valcourt |
| Author | Lindsay B. Alcaraz |
| Author | Jean-Yves Exposito |
| Author | Claire Lethias |
| Author | Laurent Bartholin |
| Abstract | Tenascin-X is the largest member of the tenascin (TN) family of evolutionary conserved extracellular matrix glycoproteins, which also comprises TN-C, TN-R and TN-W. Among this family, TN-X is the only member described so far to exert a crucial architectural function as evidenced by a connective tissue disorder (a recessive form of Ehlers-Danlos syndrome) resulting from a loss-of-function of this glycoprotein in humans and mice. However, TN-X is more than an architectural protein, as it displays features of a matricellular protein by modulating cell adhesion. However, the cellular functions associated with the anti-adhesive properties of TN-X have not yet been revealed. Recent findings indicate that TN-X is also an extracellular regulator of signaling pathways. Indeed, TN-X has been shown to regulate the bioavailability of the Transforming Growth Factor (TGF)-? and to modulate epithelial cell plasticity. The next challenges will be to unravel whether the signaling functions of TN-X are functionally linked to its matricellular properties. |
| Publication | Cell Adhesion & Migration |
| Volume | 9 |
| Issue | 1-2 |
| Pages | 154-165 |
| Date | 2015 |
| Journal Abbr | Cell Adh Migr |
| Language | eng |
| DOI | 10.4161/19336918.2014.994893 |
| ISSN | 1933-6926 |
| Short Title | Tenascin-X |
| Library Catalog | PubMed |
| Extra | PMID: 25793578 PMCID: PMC4422802 |
| Tags | Animals, Cell Adhesion, cell signaling, ECM, extracellular matrix, EDS, Ehlers-Danlos syndrome, EGF, epidermal growth factor, Ehlers-Danlos syndrome (EDS), EMT, epithelial-to-mesenchymal transition, Epithelial Cells, epithelial-to-mesenchymal transition (EMT), FAK, focal adhesion kinase, FBG, fibrinogen-like domain, FNIII, fibronectin type III module, Homeostasis, Humans, integrin ?11?1, LAP, latency associated peptide, matricellular protein, MMP, matrix metalloproteinase, review, Signal Transduction, SLC, small latent complex, Tenascin, tenascin-X, TGF-?, TGF-? activation, TN, tenascin, Transforming Growth Factor beta, transforming growth factor-?, TSP-1, thrombospondin-1, VEGF, vascular endothelial growth factor |
| Date Added | 2019/05/28 - 17:27:55 |
| Date Modified | 2019/05/29 - 13:11:36 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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