| Added by | pcoopman |
|---|---|
| Last modified by | standudu |
| Group name | EquipePC |
| Item Type | Journal Article |
| Title | Decision of Adjuvant Systemic Treatment in HR+ HER2- Early Invasive Breast Cancer: Which Biomarkers Could Help? |
| Creator | Alexandre et al. |
| Author | Marie Alexandre |
| Author | Aurélie Maran-Gonzalez |
| Author | Marie Viala |
| Author | Nelly Firmin |
| Author | Véronique D'Hondt |
| Author | Marian Gutowski |
| Author | Céline Bourgier |
| Author | William Jacot |
| Author | Séverine Guiu |
| Abstract | The decision to administer adjuvant chemotherapy in treatment of early invasive breast cancer (EBC) is often complex, particularly for hormone receptor-positive (HR+) diseases, and current guidelines often classify these patients in an intermediate-risk group. Several biomarkers are currently available in this indication, in order to obtain additional and more accurate prognostic information compared to classic clinicopathological characteristics and guide the indication of adjuvant chemotherapy, optimizing the efficacy/toxicity ratio. We conducted a systematic review to evaluate the clinical validity and clinical utility of five biomarkers (uPA/PAI-1, OncotypeDX®, MammaPrint®, PAM50, and EndoPredict®) in HR+/HER2- EBC, whatever the nodal status. A total of 89 studies met the inclusion criteria. Even though data currently available confirm the clinical validity of these biomarkers, there is a lack of data regarding clinical utility for most of them. Prospective studies in well-defined populations are needed to integrate these biomarkers in a decision strategy. |
| Publication | Cancer Management and Research |
| Volume | 11 |
| Pages | 10353-10373 |
| Date | 2019 |
| Journal Abbr | Cancer Manag Res |
| Language | eng |
| DOI | 10.2147/CMAR.S221676 |
| ISSN | 1179-1322 |
| Short Title | Decision of Adjuvant Systemic Treatment in HR+ HER2- Early Invasive Breast Cancer |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 31849525 PMCID: PMC6912012 |
| Tags | breast cancer, clinic |
| Date Added | 2020/07/17 - 17:59:13 |
| Date Modified | 2020/10/04 - 14:01:58 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
