| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Clinicopathological Correlates of ?? T Cell Infiltration in Triple-Negative Breast Cancer |
| Creator | Boissière-Michot et al. |
| Author | Florence Boissière-Michot |
| Author | Ghita Chabab |
| Author | Caroline Mollevi |
| Author | Séverine Guiu |
| Author | Evelyne Lopez-Crapez |
| Author | Jeanne Ramos |
| Author | Nathalie Bonnefoy |
| Author | Virginie Lafont |
| Author | William Jacot |
| Abstract | The prognostic impact of the different tumor-infiltrating lymphocyte (TIL) subpopulations in solid cancers is still debated. Here, we investigated the clinicopathological correlates and prognostic impact of TILs, particularly of ?? T cells, in 162 patients with triple-negative breast cancer (TNBC). A high ?? T cell density (>6.625 ?? T cells/mm2) was associated with younger age (p = 0.008), higher tumor histological grade (p = 0.002), adjuvant chemotherapy (p = 0.010), BRCA1 promoter methylation (p = 0.010), TIL density (p < 0.001), and PD-L1 (p < 0.001) and PD-1 expression (p = 0.040). In multivariate analyses, ?? T cell infiltration (cutoff = 6.625 ?? T cells/mm2) was an independent prognostic factor (5-year relapse-free survival: 63.3% vs. 89.8%, p = 0.027; 5-year overall survival: 73.8% vs. 89.9%, p = 0.031, for low vs. high infiltration). This prognostic impact varied according to the tumor PIK3CA mutational status. High ?? T cell infiltration was associated with better survival in patients with PIK3CA wild-type tumors, but the difference was not significant in the subgroup with PIK3CA-mutated tumors. Altogether, these data suggest that high ?? T cell infiltrate is correlated with immune infiltration and might represent a candidate prognostic tool in patients with TNBC. |
| Publication | Cancers |
| Volume | 13 |
| Issue | 4 |
| Pages | 765 |
| Date | 2021-02-12 |
| Journal Abbr | Cancers (Basel) |
| Language | eng |
| DOI | 10.3390/cancers13040765 |
| ISSN | 2072-6694 |
| Library Catalog | PubMed |
| Extra | PMID: 33673133 PMCID: PMC7918092 |
| Tags | ?? T cells, basal-like, BRCA1, first-last-corresponding, last, marque, original, PIK3CA |
| Date Added | 2022/07/29 - 15:53:10 |
| Date Modified | 2022/08/01 - 16:19:45 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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