| Added by | llasorsa |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Development and Validation of a Simplified Prognostic Score in SCLC |
| Creator | Negre et al. |
| Author | Elodie Negre |
| Author | Amandine Coffy |
| Author | Alexandra Langlais |
| Author | Jean-Pierre Daures |
| Author | Armelle Lavole |
| Author | Elisabeth Quoix |
| Author | Olivier Molinier |
| Author | Laurent Greillier |
| Author | Clarisse Audigier-Valette |
| Author | Denis Moro-Sibilot |
| Author | Virginie Westeel |
| Author | Franck Morin |
| Author | Benoît Roch |
| Author | Jean-Louis Pujol |
| Abstract | INTRODUCTION: This study aimed at generating a new simplified prognostic score (SPS) using common clinical and biological variables to discriminate a limited number of subgroups of patients with SCLC differing by their overall survival (OS). METHODS: The SPS was developed exploring the Montpellier University Hospital retrospective database of 401 patients over a 16-year period. All patients had received etoposide - platinum-based chemotherapy as first-line treatment. The SPS development took into account significant determinants of OS in the Cox model, weighted by their regression ? coefficients. Validation of the consequent SPS has been done separately in a combined population of 213 patients accrued from two different published trials (NCT03059667 and NCT00930891). RESULTS: The significant independent determinants of OS included the following: (1) American Joint Committee on Cancer TNM stage IV (hazard ratio [HR]: 2.52; 95% confidence interval [CI]: 1.91-3.33); (2) Eastern Cooperative Oncology Group performance status greater than 1 (HR: 2.27; 95% CI: 1.79-2.87); (3) the presence of liver metastases (HR: 1.66; 95% CI: 1.29-2.15); and (4) neutrophil-to-lymphocyte ratio greater than 4 (HR: 1.39; 95% CI: 1.11-1.92). The SPS generated with these four variables, segregated three groups (good, intermediate, and poor prognosis) with respective median OS of 26.9 months (95% CI: 20.1-38.9), 11.5 months (95% CI: 9.8-13.0), and 6.8 months (95% CI: 5.8-8.3; log-rank p < 10-4). Harrell's C statistic estimate was 0.68 ± 0.012, suggesting goodness of calibration. In the validation cohort, the SPS segregated the aforementioned three subgroups in a nearly similar manner, with respective median OS: 27.2, 12.3, and 8.6 months (log-rank p < 10-3; Harrell's C statistic: 0.58 ± 0.02). CONCLUSIONS: The SPS is easy to calculate in real-life practice and efficiently discriminates three populations with different prognoses. This study deserves further validation of this score in patients with SCLC receiving immunochemotherapy. |
| Publication | JTO clinical and research reports |
| Volume | 1 |
| Issue | 1 |
| Pages | 100016 |
| Date | 2020-03 |
| Journal Abbr | JTO Clin Res Rep |
| Language | eng |
| DOI | 10.1016/j.jtocrr.2020.100016 |
| ISSN | 2666-3643 |
| Library Catalog | PubMed |
| Extra | Code: JTO clinical and research reports PMID: 34589918 PMCID: PMC8474253 |
| Tags | Chemotherapy, Prognosis, Prognostic score, Serum markers, Small cell lung cancer |
| Date Added | 2022/09/16 - 17:03:47 |
| Date Modified | 2024/10/10 - 16:59:02 |
| Notes and Attachments | PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) Texte intégral (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
