| Added by | llasorsa |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Image-Guided Liver Stereotactic Body Radiotherapy Using VMAT and Real-Time Adaptive Tumor Gating: Evaluation of the Efficacy and Toxicity for Hepatocellular Carcinoma |
| Creator | Cantaloube et al. |
| Author | Marie Cantaloube |
| Author | Florence Castan |
| Author | Morgane Creoff |
| Author | Jessica Prunaretty |
| Author | Karl Bordeau |
| Author | Morgan Michalet |
| Author | Eric Assenat |
| Author | Boris Guiu |
| Author | Georges-Philippe Pageaux |
| Author | Marc Ychou |
| Author | Pascal Fenoglietto |
| Author | David Azria |
| Author | Olivier Riou |
| Abstract | Liver SBRT is a therapeutic option for the treatment of HCC in patients not eligible for other local therapies. We retrospectively report the outcomes of a cohort of consecutive patients treated with SBRT for HCC at the Montpellier Cancer Institute. Between March 2013 and December 2018, 66 patients were treated with image-guided liver SBRT using VMAT and real-time adaptive tumor gating in our institute. The main endpoints considered in this study were local control, disease-free survival, overall survival, and toxicity. The median follow-up was 16.8 months. About 66.7% had prior liver treatment. Most patients received 50 Gy in five fractions of 10 Gy. No patient had local recurrence. Overall survival and disease-free survival were, respectively, 83.9% and 46.7% at one year. In multivariate analysis, the diameter of the lesions was a significant prognostic factor associated with disease-free survival (HR = 2.57 (1.19-5.53) p = 0.02). Regarding overall survival, the volume of PTV was associated with lower overall survival (HR = 2.84 (1.14-7.08) p = 0.025). No grade 3 toxicity was observed. One patient developed a grade 4 gastric ulcer, despite the dose constraints being respected. Image-guided liver SBRT with VMAT is an effective and safe treatment in patients with inoperable HCC, even in heavily pre-treated patients. Further prospective evaluation will help to clarify the role of SBRT in the management of HCC patients. |
| Publication | Cancers |
| Volume | 13 |
| Issue | 19 |
| Pages | 4853 |
| Date | 2021-09-28 |
| Journal Abbr | Cancers (Basel) |
| Language | eng |
| DOI | 10.3390/cancers13194853 |
| ISSN | 2072-6694 |
| Short Title | Image-Guided Liver Stereotactic Body Radiotherapy Using VMAT and Real-Time Adaptive Tumor Gating |
| Library Catalog | PubMed |
| Extra | PMID: 34638336 PMCID: PMC8507769 |
| Tags | hepatocellular carcinoma, stereotactic body radiation therapy, VMAT |
| Date Added | 2022/08/30 - 16:27:14 |
| Date Modified | 2024/10/10 - 16:53:50 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
