| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | Oncological Outcomes after Liver Venous Deprivation for Colorectal Liver Metastases: A Single Center Experience |
| Creator | Khayat et al. |
| Author | Salah Khayat |
| Author | Gianluca Cassese |
| Author | Christophe Cassinotto |
| Author | Eric Assenat |
| Author | Francis Navarro |
| Author | Boris Guiu |
| Author | Fabrizio Panaro |
| Abstract | Colorectal liver metastases (CRLM) are the major cause of death in patients with colorectal cancer (CRC). The cornerstone treatment of CRLM is surgical resection. Post-operative morbidity and mortality are mainly linked to an inadequate future liver remnant (FLR). Nowadays preoperative portal vein embolization (PVE) is the most widely performed technique to increase the size of the future liver remnant (FLR) before major hepatectomies. One method recently proposed to increase the FLR is liver venous deprivation (LVD), but its oncological impact is still unknown. The aim of this study is to report first short- and long-term oncological outcomes after LVD in patients undergoing right (or extended right) hepatectomy for CRLM. Seventeen consecutive patients undergoing LVD between July 2015 and May 2020 before an (extended) right hepatectomy were retrospectively analyzed from an institutional database. Post-operative and follow-up data were analyzed and reported. Primary outcomes were 1-year and 3-year overall survival (OS) and hepatic recurrence (HR). Postoperative complications occurred in 8 patients (47%). No deaths occurred after surgery. HR occurred in 9 patients (52.9%). 1-year and 3-year OS were 87% (95% confidence interval [CI]: ±16%) and 60.3%, respectively (95% CI: ±23%). Median Disease-Free Survival (DFS) was 6 months (CI 95%: 4.7-7.2). With all the limitations of a retrospective study with a small sample size, LVD showed similar oncological outcomes compared to literature reports for Portal Vein Embolization (PVE). |
| Publication | Cancers |
| Volume | 13 |
| Issue | 2 |
| Date | 2021-01-08 |
| Journal Abbr | Cancers (Basel) |
| Language | eng |
| DOI | 10.3390/cancers13020200 |
| ISSN | 2072-6694 |
| Short Title | Oncological Outcomes after Liver Venous Deprivation for Colorectal Liver Metastases |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 33429913 PMCID: PMC7826613 |
| Tags | clinic, colorectal liver metastasis, future liver remnant, oncological outcomes |
| Date Added | 2021/02/05 - 09:39:25 |
| Date Modified | 2021/05/07 - 14:11:37 |
| Notes and Attachments | Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
