| Added by | mollevi |
|---|---|
| Last modified by | Cavailles |
| Group name | EquipeVC |
| Item Type | Journal Article |
| Title | Development of a molecular recognition based approach for multi-residue extraction of estrogenic endocrine disruptors from biological fluids coupled to liquid chromatography-tandem mass spectrometry measurement |
| Creator | Bousoumah et al. |
| Author | R. Bousoumah |
| Author | J. P. Antignac |
| Author | V. Camel |
| Author | M. Grimaldi |
| Author | P. Balaguer |
| Author | F. Courant |
| Author | E. Bichon |
| Author | M. L. Morvan |
| Author | B. Le Bizec |
| Abstract | Multi-residue methods permitting the high-throughput and affordable simultaneous determination of an extended range of endocrine disrupting chemicals (EDCs) with reduced time and cost of analysis is of prime interest in order to characterize a whole set of bioactive compounds. Such a method based on UHPLC-MS/MS measurement and dedicated to 13 estrogenic EDCs was developed and applied to biological matrices. Two molecular recognition-based strategies, either molecular imprinted polymer (MIP) with phenolic template or estrogen receptors (ERalpha) immobilized on a sorbent, were assessed in terms of recovery and purification efficiency. Both approaches demonstrated their suitability to measure ultra-trace levels of estrogenic EDCs in aqueous samples. Applicability of the MIP procedure to urine and serum samples has also been demonstrated. |
| Publication | Anal Bioanal Chem |
| Volume | 407 |
| Issue | 29 |
| Pages | 13-23 |
| Date | Sep 21 2015 |
| Journal Abbr | Analytical and bioanalytical chemistry |
| ISSN | 1618-2650 (Electronic) |
| Tags | original |
| Date Added | 2018/11/14 - 12:10:52 |
| Date Modified | 2019/05/17 - 11:42:06 |
| Notes and Attachments | (Note) (Note) 26391401 (Attachment) |
Institut de Recherche en Cancérologie de
