Added by |
jacques.colinge |
Group name |
EquipeJC |
Item Type |
Journal Article |
Title |
The Prognostic Impact of the Aryl Hydrocarbon Receptor (AhR) in Primary Breast Cancer Depends on the Lymph Node Status. |
Creator |
Jeschke et al. |
Author |
Udo Jeschke |
Author |
Xi Zhang |
Author |
Christina Kuhn |
Author |
Jacques Colinge |
Author |
Kristina Pfender |
Author |
Doris Mayr |
Author |
Nina Ditsch |
Author |
Nadia Harbeck |
Author |
Sven Mahner |
Author |
Sophie Sixou |
Abstract |
Increasing evidence implicates the aryl hydrocarbon receptor (AhR) as a possible regulator of mammary carcinogenesis. This study aims to clarify its prognostic impact in breast cancer (BC). Meta-analyses performed at the mRNA level demonstrated that the predictive value of AhR expression in BC depends on the lymph node (LN) status. AhR expression and sub-cellular location were then analyzed by immunohistochemistry in 302 primary BC samples. AhR was expressed in almost 90% of cases with a predominant nuclear location. Nuclear and cytoplasmic AhR levels were significantly correlated and associated with the expression of RIP140 (receptor-interacting protein of 140 kDa), an AhR transcriptional coregulator and target gene. Interestingly, total and nuclear AhR levels were only significantly correlated with short overall survival in node-negative patients. In this sub-group, total and nuclear AhR expression had an even stronger prognostic impact in patients with low RIP140-expressing tumors. Very interestingly, the total AhR prognostic value was also significant in luminal-like BCs and was an independent prognostic marker for LN-negative patients. Altogether, this study suggests that AhR is a marker of poor prognosis for patients with LN-negative luminal-like BCs, which warrants further evaluation. |
Publication |
International journal of molecular sciences |
Volume |
20 |
Issue |
5 |
Date |
2019 Feb 26 |
Journal Abbr |
Int J Mol Sci |
Language |
eng |
DOI |
10.3390/ijms20051016 |
ISSN |
1422-0067 1422-0067 |
Extra |
PMID: 30813617
PMCID: PMC6429124 |
Tags |
AhR, breast cancer, luminal-like, lymph node, original, prognostic marker, RIP140 |
Date Added |
2019/05/14 - 20:52:46 |
Date Modified |
2019/05/14 - 21:03:16 |