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Epitranscriptomics & Cancer Adaptation : A.David

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Our research work focuses on the contribution of post-transcriptional mechanisms on cancer cell adaptation, in particular RNA epigenetic & translational control.

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Added by mollevi
Last modified by pcoopman
Group name EquipePC
Item Type Journal Article
Title Use of autoantibodies to detect the onset of breast cancer
Creator Lacombe et al.
Author J. Lacombe
Author A. Mange
Author J. Solassol
Abstract The widespread use of screening mammography has resulted in increased detection of early-stage breast disease, particularly for in situ carcinoma and early-stage breast cancer. However, the majority of women with abnormalities noted on screening mammograms are not diagnosed with cancer because of several factors, including radiologist assessment, patient age, breast density, malpractice concerns, and quality control procedures. Although magnetic resonance imaging is a highly sensitive detection tool that has become standard for women at very high risk of developing breast cancer, it lacks sufficient specificity and costeffectiveness for use as a general screening tool. Therefore, there is an important need to improve screening and diagnosis of early-invasive and noninvasive tumors, that is, in situ carcinoma. The great potential for molecular tools to improve breast cancer outcomes based on early diagnosis has driven the search for diagnostic biomarkers. Identification of tumor-specific markers capable of eliciting an immune response in the early stages of tumor development seems to provide an effective approach for early diagnosis. The aim of this review is to describe several autoantibodies identified during breast cancer diagnosis. We will focus on these molecules highlighted in the past two years and discuss the potential future use of autoantibodies as biomarkers of early-stage breast cancer.
Publication J Immunol Res
Volume 2014
Pages 574981
Date 2014
Journal Abbr Journal of immunology research
DOI 10.1155/2014/574981
ISSN 2314-7156 (Electronic) 2314-7156 (Linking)
Tags *Tumor Markers, Biological, Antigens, Neoplasm/immunology, Autoantibodies/*diagnostic use/immunology, Breast Neoplasms/*diagnosis/immunology/pathology, Early Detection of Cancer, Female, Humans, orig, original
Date Added 2018/11/14 - 12:07:50
Date Modified 2019/05/28 - 10:33:42
Notes and Attachments (Note)
(Note)
25143958 (Attachment)


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