| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | Hepatobiliary Scintigraphy and Glass 90Y Radioembolization with Personalized Dosimetry: Dynamic Changes in Treated and Nontreated Liver |
| Creator | Allimant et al. |
| Author | Carole Allimant |
| Author | Emmanuel Deshayes |
| Author | Marilyne Kafrouni |
| Author | Lore Santoro |
| Author | Marjolaine Fourcade |
| Author | Christophe Cassinotto |
| Author | Margaux Hermida |
| Author | Chloé Guillot |
| Author | Denis Mariano-Goulart |
| Author | Boris Guiu |
| Abstract | Background: The functional changes that occur over time in the liver following 90Y-radioembolization (RE) using personalized dosimetry (PD) remain to be investigated. Methods: November 2016 - October 2019: we retrospectively included hepatocellular carcinoma (HCC) patients treated by 90Y-glass RE using PD, who underwent hepatobiliary scintigraphy (HBS) at baseline and at 15 days, 1, 2, 3, and 6 months after RE. Results: There were 16 patients with unilobar disease (100%) included, and 64 HBS were performed. Whole liver function significantly decreased over time. The loss was maximal at 2 weeks: ?32% (p = 0.002) and remained below baseline at 1 (?15%; p = 0.002), 2 (?25%; p < 0.001), and 3 months (?16%; p = 0.027). No radioembolization-induced liver disease was observed. Treated liver function strongly decreased to reach ?64% (p < 0.001) at 2 months. Nontreated liver function decreased at 2 weeks (?21%; p = 0.027) and remained below baseline before reaching +20% (p = 0.002) and +59% (p < 0.001) at 3 and 6 months, respectively. Volumetric and functional changes exhibited parallel evolutions in the treated livers (p = 0.01) but independent evolutions in the nontreated livers (p = 0.08). Conclusion: RE using PD induces significant regional changes in liver function over time. As early as 15 days following RE, both the treated and nontreated livers showed a decreased function. Nontreated liver function recovered after 3 months and greatly increased afterwards. |
| Publication | Diagnostics |
| Volume | 11 |
| Issue | 6 |
| Pages | 931 |
| Date | 2021-05-21 |
| Journal Abbr | Diagnostics |
| Language | en |
| DOI | 10.3390/diagnostics11060931 |
| ISSN | 2075-4418 |
| Short Title | Hepatobiliary Scintigraphy and Glass 90Y Radioembolization with Personalized Dosimetry |
| URL | https://www.mdpi.com/2075-4418/11/6/931 |
| Accessed | 2023/11/23 - 12:22:14 |
| Library Catalog | DOI.org (Crossref) |
| Extra | Number: 6 |
| Tags | clinic, hepatobiliary scintigraphy, mebrofenin, selective internal radiation therapy |
| Date Added | 2023/11/23 - 12:44:41 |
| Date Modified | 2024/12/15 - 11:27:16 |
| Notes and Attachments | Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
