| Added by | mollevi |
|---|---|
| Group name | PlateformePCC |
| Item Type | Journal Article |
| Title | A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/?-Catenin Pathway |
| Creator | Grimaldi et al. |
| Author | Marina Grimaldi |
| Author | Abdelhay Boulahtouf |
| Author | Corinne Prévostel |
| Author | Alain Thierry |
| Author | Patrick Balaguer |
| Author | Philippe Blache |
| Abstract | A constitutive activation of the Wnt/?-catenin pathway is an initiating event in colon carcinogenesis. We developed colon cancer cells models that highlight the non-selectivity of previously described inhibitors of the Wnt pathway and we propose our model as a suitable screening system for inhibitors of the pathway. |
| Publication | Frontiers in Pharmacology |
| Volume | 9 |
| Pages | 1160 |
| Date | 2018 |
| Journal Abbr | Front Pharmacol |
| Language | eng |
| DOI | 10.3389/fphar.2018.01160 |
| ISSN | 1663-9812 |
| Library Catalog | PubMed |
| Extra | PMID: 30364258 PMCID: PMC6193374 |
| Tags | cell models, colorectal cancer, high-throughput screening, inhibitors, original, Wnt/?-catenin pathway |
| Date Added | 2019/06/04 - 17:05:38 |
| Date Modified | 2019/06/05 - 11:04:30 |
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