| Added by | Cavailles |
|---|---|
| Group name | EquipeVC |
| Item Type | Journal Article |
| Title | Association between fetal DES-exposure and psychiatric disorders in adolescence/adulthood: evidence from a French cohort of 1002 prenatally exposed children |
| Creator | Soyer-Gobillard et al. |
| Author | Marie-Odile Soyer-Gobillard |
| Author | Françoise Paris |
| Author | Laura Gaspari |
| Author | Philippe Courtet |
| Author | Charles Sultan |
| Abstract | In utero diethylstilbestrol (DES) exposure has been demonstrated to be associated with somatic abnormalities in adult men and women. Conversely, the data are contradictory regarding the association with psychological or psychiatric disorders during adolescence and adulthood. This work was designed to determine whether prenatal exposure to DES affects brain development and whether it is associated with psychiatric disorders in male and female adolescents and young adults. HHORAGES Association, a national patient support group, has assembled a cohort of 1280 women who took DES during pregnancy. We obtained questionnaire responses from 529 families, corresponding to 1182 children divided into three groups: Group 1 (n?=?180): firstborn children without DES treatment, Group 2 (n?=?740): exposed children, and Group 3 (n?=?262): children born after a previous pregnancy treated by DES. No psychiatric disorders were reported in Group 1. In Group 2, the incidence of disorders was drastically elevated (83.8%), and in Group 3, the incidence was still elevated (6.1%) compared with the general population. This work demonstrates that prenatal exposure to DES is associated with a high risk of psychiatric disorders in adolescence and adulthood. |
| Publication | Gynecological Endocrinology: The Official Journal of the International Society of Gynecological Endocrinology |
| Volume | 32 |
| Issue | 1 |
| Pages | 25-29 |
| Date | 2016 |
| Journal Abbr | Gynecol. Endocrinol. |
| Language | eng |
| DOI | 10.3109/09513590.2015.1063604 |
| ISSN | 1473-0766 |
| Short Title | Association between fetal DES-exposure and psychiatric disorders in adolescence/adulthood |
| Library Catalog | PubMed |
| Extra | PMID: 26172930 |
| Tags | Adolescence, Adolescent, Adult, adulthood, Bipolar Disorder, Case-Control Studies, clinic, Cohort Studies, Depressive Disorder, Diethylstilbestrol, Estrogens, Non-Steroidal, Female, France, Humans, Incidence, Male, Mental Disorders, Pregnancy, prenatal DES exposure, Prenatal Exposure Delayed Effects, psychiatric disorders, Schizophrenia, Siblings, Suicide, Suicide, Attempted, Surveys and Questionnaires, Young Adult |
| Date Added | 2019/05/16 - 15:06:20 |
| Date Modified | 2019/05/16 - 15:23:24 |
| Notes and Attachments | PubMed entry (Attachment) |
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