| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation |
| Creator | Guénolé et al. |
| Author | Aude Guénolé |
| Author | Fabien Velilla |
| Author | Aymeric Chartier |
| Author | April Rich |
| Author | Anne-Ruxandra Carvunis |
| Author | Claude Sardet |
| Author | Martine Simonelig |
| Author | Bijan Sobhian |
| Abstract | Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization. Here, we show that the RING finger protein RNF219 co-purifies with the CCR4-NOT complex, the major mRNA deadenylase in eukaryotes, which mediates translational repression in both a deadenylase activity-dependent and -independent manner. Strikingly, RNF219 both inhibits the deadenylase activity of CCR4-NOT and enhances its capacity to repress translation of a target mRNA. We propose that the interaction of RNF219 with the CCR4-NOT complex directs the translational repressive activity of CCR4-NOT to a deadenylation-independent mechanism. |
| Publication | Scientific Reports |
| Volume | 12 |
| Issue | 1 |
| Pages | 9288 |
| Date | 2022-06-03 |
| Journal Abbr | Sci Rep |
| Language | eng |
| DOI | 10.1038/s41598-022-13309-8 |
| ISSN | 2045-2322 |
| Library Catalog | PubMed |
| Extra | PMID: 35660762 PMCID: PMC9166816 |
| Tags | first, Gene Expression Regulation, marque, original, Protein Biosynthesis, Ribonucleases, RNA Stability, RNA, Messenger |
| Date Added | 2022/07/29 - 11:36:06 |
| Date Modified | 2023/11/14 - 14:46:00 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
