Research
Epitranscriptomics & Cancer Adaptation : A.David

Activities

Our research work focuses on the contribution of post-transcriptional mechanisms on cancer cell adaptation, in particular RNA epigenetic & translational control.

More..

Zotero public

Added by adjiane.lab
Group name EquipeAD
Item Type Journal Article
Title A prospective clinical and biological database for pancreatic adenocarcinoma: the BACAP cohort
Creator Canivet et al.
Author Cindy Canivet
Author Sophie Gourgou-Bourgade
Author Bertrand Napoléon
Author Laurent Palazzo
Author Nicolas Flori
Author Pierre Guibert
Author Guillaume Piessen
Author Dominique Farges-Bancel
Author Jean-François Seitz
Author Eric Assenat
Author Véronique Vendrely
Author Stéphanie Truant
Author Geoffroy Vanbiervliet
Author Philippe Berthelémy
Author Stéphane Garcia
Author Anne Gomez-Brouchet
Author Louis Buscail
Author Barbara Bournet
Abstract BACKGROUND: The prognosis for pancreatic cancer remains poor despite diagnostic advances and treatments with new chemotherapeutic regimens. The five year survival rate remains below 3%. Consequently, there is an urgent need for new treatments to significantly improve the prognosis. In addition, there is a big gap in terms of the screening, early diagnosis and prevention of pancreatic cancer the incidence of which is increasing dramatically. METHODS: Design: the BACAP cohort is a prospective multicenter pancreatic cancer cohort (pancreatic ductal carcinoma) with clinical and multiple biological samples; Participating centers: 15 French academic and private hospitals; Study Population: any cytologically and/or histologically proven pancreatic carcinoma regardless of the stage (resectable, borderline, locally advanced or metastatic) or treatment (surgery, palliative chemotherapy, best supportive care). At least 1500 patients will be included. Clinical data collected include: disease presentation, epidemiological and social factors, baseline biology, radiology, endoscopic ultrasound, staging, pathology, treatments, follow-up (including biological and radiological), and survival. All these data are collected and stored through an e-observation system at a centralized data center. Biological samples and derived products (i.e. before any treatment): blood, saliva, endoscopic ultrasound-guided fine needle aspiration materials from the primary tumor, fine needle biopsy of metastases and surgically resected tissue. DNA and RNA are extracted from fine needle aspiration materials and are quantified and characterized for quality. Whole blood, plasma and serum are isolated from blood samples. Frozen tissues were specifically allocated to the cohort. All derived products and saliva are stored at -?80 °C. Main end-points: i) to centralize clinical data together with multiple biological samples that are harmonized in terms of sampling, the post sampling process and storage; ii) to identify new molecular markers for the diagnosis, prognosis and possibly the predictive response to pancreatic cancer surgery and or chemotherapy. DISCUSSION: The BACAP cohort is a unique prospective biological clinical database that provides the opportunity to identify correlations between the presence/expression of a broad panel of biomarkers (DNA, RNA, miRNA, proteins, etc.), epidemiological and social data, various clinical situations, various stages and the differentiation of the tumor, treatments and survival. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02818829 . Registration date: June 30, 2016.
Publication BMC cancer
Volume 18
Issue 1
Pages 986
Date 2018-10-16
Journal Abbr BMC Cancer
Language eng
DOI 10.1186/s12885-018-4906-4
ISSN 1471-2407
Short Title A prospective clinical and biological database for pancreatic adenocarcinoma
Library Catalog PubMed
Extra PMID: 30326968 PMCID: PMC6191891
Tags Aged, Biobank, Biomarkers, Biomarkers, Tumor, Carcinoma, Pancreatic Ductal, clinic, Cohort Studies, Cohort study, Databases as Topic, DNA, Female, France, Humans, Male, Middle Aged, Outcomes, Pancreatic adenocarcinoma, Pancreatic Neoplasms, Prognosis, Quality control, RNA
Date Added 2024/09/30 - 01:32:01
Date Modified 2024/09/30 - 18:22:13
Notes and Attachments Full Text (Attachment)
PubMed entry (Attachment)


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés