| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | Antiviral (Hepatitis C Virus) Drug-Drug Interaction Leading to Dramatic Underestimation of Liver Function With 99mTc-Mebrofenin Hepatobiliary Scintigraphy |
| Creator | Deshayes et al. |
| Author | Emmanuel Deshayes |
| Author | Cyril Fersing |
| Author | Lucy Meunier |
| Author | Boris Guiu |
| Abstract | There is a growing interest in assessment of future remnant liver function with Tc-mebrofenin hepatobiliary scintigraphy before major hepatectomy to estimate the risk of posthepatectomy liver failure. We illustrate the case of a 42-year-old woman with liver metastasis from colorectal cancer who performed hepatobiliary scintigraphy. Tc-mebrofenin clearance rate of the total liver was considerably low. The patient recently started a treatment for active hepatitis C with a combination of 2 new direct-acting antiviral agents (grazoprevir, elbasvir). Apart from hypoalbuminemia or hyperbilirubinemia, physicians must be aware that drug interactions can interfere with Tc-mebrofenin liver uptake, thereby resulting in a dramatic underestimation of liver function. |
| Publication | Clinical Nuclear Medicine |
| Volume | 45 |
| Issue | 2 |
| Pages | 133-135 |
| Date | Feb 2020 |
| Journal Abbr | Clin Nucl Med |
| Language | eng |
| DOI | 10.1097/RLU.0000000000002861 |
| ISSN | 1536-0229 |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 31833927 |
| Tags | clinic |
| Date Added | 2020/01/03 - 10:25:48 |
| Date Modified | 2020/01/03 - 10:25:56 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
