| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Treatment and outcomes in patients with central nervous system metastases from breast cancer in the real-life ESME MBC cohort |
| Creator | Pasquier et al. |
| Author | David Pasquier |
| Author | Amélie Darlix |
| Author | Guillaume Louvel |
| Author | Julien Fraisse |
| Author | William Jacot |
| Author | Etienne Brain |
| Author | Adeline Petit |
| Author | Marie Ange Mouret-Reynier |
| Author | Anthony Goncalves |
| Author | Florence Dalenc |
| Author | Elise Deluche |
| Author | Jean Sébastien Fresnel |
| Author | Paule Augereau |
| Author | Jean Marc Ferrero |
| Author | Julien Geffrelot |
| Author | Jean-David Fumet |
| Author | Isabelle Lecouillard |
| Author | Paul Cottu |
| Author | Thierry Petit |
| Author | Lionel Uwer |
| Author | Christelle Jouannaud |
| Author | Marianne Leheurteur |
| Author | Véronique Dieras |
| Author | Mathieu Robain |
| Author | Raphaelle Mouttet-Audouard |
| Author | Thomas Bachelot |
| Author | Coralie Courtinard |
| Abstract | AIM: The aims of the present study were to describe treatment patterns and survival outcomes in patients with central nervous system metastases (CNSM) selected among metastatic breast cancer (MBC) patients included in a retrospective study from the Epidemiological Strategy and Medical Economics (ESME) MBC cohort. METHODS: Neurological progression-free survival (NPFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Signi?cant contributors to NPFS were determined using a multivariate Cox proportional hazards model. RESULTS: After a median follow-up of 42.8 months, of 16 701 patients included in the ESME MBC database, CNSM were diagnosed in 24.6% of patients. The most frequent treatments after diagnosis of CNSM were whole-brain radiotherapy (WBRT) (45.2%) and systemic treatment (59.3%). Median OS and NPFS were 7.9 months (95% CI: 7.2-8.4) and 5.5 months (95% CI: 5.2-5.8), respectively. In multivariate analysis, age >70 years (vs <50 years; HR = 1.40; 95% CI: 1.24-1.57), triple-negative tumours (vs HER2-/HR+; HR = 1.87; 95% CI: 1.71-2.06), HER2+/HR-tumours (vs HER2-/HR+; HR = 1.14; 95% CI: 1.02-1.27), ?3 metastatic sites (vs < 3; HR = 1.32; 95% CI: 1.21-1.43) and ?3 previous treatment lines (vs < 3; HR = 1.75; 95% CI: 1.56-1.96) were detrimental for NPFS. A time interval between selection and CNSM diagnosis superior to 18 months (vs <9 months; HR = 0.88; 95% CI: 0.78-0.98) was associated with longer NPFS. CONCLUSIONS: This study describes current treatment patterns of MBC patients in a "real life" setting. Despite advances in stereotactic radiation therapy, most of the patients still received WBRT. More research is warranted to identify patient subsets for tailored treatment strategies. |
| Publication | European Journal of Cancer (Oxford, England: 1990) |
| Volume | 125 |
| Pages | 22-30 |
| Date | Jan 2020 |
| Journal Abbr | Eur. J. Cancer |
| Language | eng |
| DOI | 10.1016/j.ejca.2019.11.001 |
| ISSN | 1879-0852 |
| Library Catalog | PubMed |
| Extra | PMID: 31835235 |
| Tags | Brain metastases, clinic, Neurological progression-free survival |
| Date Added | 2020/01/21 - 10:46:14 |
| Date Modified | 2020/01/21 - 10:57:52 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
