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Added by mollevi
Last modified by jacques.colinge
Group name EquipeJC
Item Type Journal Article
Title Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions
Creator Silva et al.
Author J. C. Silva
Author E. Cornillot
Author C. McCracken
Author S. Usmani-Brown
Author A. Dwivedi
Author O. O. Ifeonu
Author J. Crabtree
Author H. T. Gotia
Author A. Z. Virji
Author C. Reynes
Author J. Colinge
Author V. Kumar
Author L. Lawres
Author J. E. Pazzi
Author J. V. Pablo
Author C. Hung
Author J. Brancato
Author P. Kumari
Author J. Orvis
Author K. Tretina
Author M. Chibucos
Author S. Ott
Author L. Sadzewicz
Author N. Sengamalay
Author A. C. Shetty
Author Q. Su
Author L. Tallon
Author C. M. Fraser
Author R. Frutos
Author D. M. Molina
Author P. J. Krause
Author C. Ben Mamoun
Abstract Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis. While most cases are transmitted by Ixodes ticks, the disease may also be transmitted through blood transfusion and perinatally. A comprehensive analysis of genome composition, genetic diversity, and gene expression profiling of seven B. microti isolates revealed that genetic variation in isolates from the Northeast United States is almost exclusively associated with genes encoding the surface proteome and secretome of the parasite. Furthermore, we found that polymorphism is restricted to a small number of genes, which are highly expressed during infection. In order to identify pathogen-encoded factors involved in host-parasite interactions, we screened a proteome array comprised of 174 B. microti proteins, including several predicted members of the parasite secretome. Using this immuno-proteomic approach we identified several novel antigens that trigger strong host immune responses during the onset of infection. The genomic and immunological data presented herein provide the first insights into the determinants of B. microti interaction with its mammalian hosts and their relevance for understanding the selective pressures acting on parasite evolution.
Publication Sci Rep
Volume 6
Pages 35284
Date Oct 18 2016
Journal Abbr Scientific reports
DOI 10.1038/srep35284
ISSN 2045-2322 (Electronic) 2045-2322 (Linking)
Tags original, phd
Date Added 2018/11/14 - 11:48:35
Date Modified 2019/10/22 - 21:13:29
Notes and Attachments (Note)
(Note)
27752055 (Attachment)


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