| Added by | llasorsa |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Association of neutrophil extracellular traps with the production of circulating DNA in patients with colorectal cancer |
| Creator | Pastor et al. |
| Author | Brice Pastor |
| Author | Jean-Daniel Abraham |
| Author | Ekaterina Pisareva |
| Author | Cynthia Sanchez |
| Author | Andrei Kudriavstev |
| Author | Rita Tanos |
| Author | Alexia Mirandola |
| Author | Lucia Mihalovi?ová |
| Author | Veronique Pezzella |
| Author | Antoine Adenis |
| Author | Marc Ychou |
| Author | Thibault Mazard |
| Author | Alain R. Thierry |
| Abstract | We postulate that a significant part of circulating DNA (cirDNA) originates in the degradation of neutrophil extracellular traps (NETs). In this study, we examined the plasma level of two markers of NETs (myeloperoxidase (MPO) and neutrophil elastase (NE)), as well as cirDNA levels in 219 patients with a metastatic colorectal cancer (mCRC), and in 114 healthy individuals (HI). We found that in patients with mCRC the content of these analytes was (i) highly correlated, and (ii) all statistically different (p < 0.0001) than in HI (N = 114). These three NETs markers may readily distinguish between patients with mCRC from HI, (0.88, 0.86, 0.84, and 0.95 AUC values for NE, MPO, cirDNA, and NE + MPO + cirDNA, respectively). Concomitant analysis of anti-phospholipid (anti-cardiolipin), NE, MPO, and cirDNA plasma concentrations in patients with mCRC might have value for thrombosis prevention, and suggested that NETosis may be a critical factor in the immunological response/phenomena linked to tumor progression. |
| Publication | iScience |
| Volume | 25 |
| Issue | 2 |
| Pages | 103826 |
| Date | 2022-02-18 |
| Journal Abbr | iScience |
| Language | eng |
| DOI | 10.1016/j.isci.2022.103826 |
| ISSN | 2589-0042 |
| Library Catalog | PubMed |
| Extra | PMID: 35198886 PMCID: PMC8844218 |
| Tags | Molecular biology |
| Date Added | 2022/08/30 - 16:04:19 |
| Date Modified | 2024/10/10 - 16:31:50 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
