| Added by | celine.gongora |
|---|---|
| Group name | EquipeCG |
| Item Type | Journal Article |
| Title | Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination |
| Creator | Mbatchi et al. |
| Author | Litaty Céphanoée Mbatchi |
| Author | Antonin Schmitt |
| Author | Fabienne Thomas |
| Author | Yoann Cazaubon |
| Author | Jacques Robert |
| Author | Serge Lumbroso |
| Author | Jean-Paul Brouillet |
| Author | Philippe Pourquier |
| Author | Etienne Chatelut |
| Author | Jean-Christophe Boyer |
| Author | Alexandre Evrard |
| Abstract | AIM: The goal of our study was to assess the impact of patients' genetic background on their sensitivity to carboplatin/paclitaxel hematotoxicity. PATIENTS & METHODS: Parameters describing sensitivity to neutropenia and to thrombocytopenia of 201 patients were extracted from a previous pharmacokinetic/pharmacodynamics analysis, in order to assess their association with 52 candidates SNPs in 18 genes. RESULTS: Carriers of a T allele of SLCO1B3-rs4149117 were 19% less sensitive to thrombocytopenia than the homozygotes for the G allele (p = 0.00279). Carriers of two copies of the ATG haplotypes of NR1I2-rs1523130, rs3814055 and rs1523127 were 19% less sensitive to thrombocytopenia than those harboring other haplotypes (p = 0.025). CONCLUSION: Our results revealed the importance of SLCO1B3 and NR1I2 in the sensitivity to carboplatin/paclitaxel thrombocytopenia. |
| Publication | Pharmacogenomics |
| Volume | 16 |
| Issue | 13 |
| Pages | 1439-1450 |
| Date | 2015 |
| Journal Abbr | Pharmacogenomics |
| Language | eng |
| DOI | 10.2217/pgs.15.84 |
| ISSN | 1744-8042 |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 26267044 |
| Tags | Adult, Aged, Aged, 80 and over, Alleles, Antineoplastic Agents, Antineoplastic Agents, Phytogenic, canceropoleGSO, Carboplatin, clinic, Cohort Studies, drug metabolism, Female, first, Gene Frequency, Genetic Association Studies, Haplotypes, hematotoxicity, Humans, last, Linkage Disequilibrium, Male, Middle Aged, Organic Anion Transporters, Sodium-Independent, Paclitaxel, Polymorphism, Single Nucleotide, Pregnane X Receptor, PXR, Receptors, Steroid, SLCO1B3, SNP, Solute Carrier Organic Anion Transporter Family Member 1B3, Thrombocytopenia, Young Adult |
| Date Added | 2019/10/10 - 14:28:50 |
| Date Modified | 2019/10/24 - 17:20:09 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
