| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | Stereotactic MR-Guided Adaptive Radiotherapy for Pancreatic Tumors: Updated Results of the Montpellier Prospective Registry Study |
| Creator | Bordeau et al. |
| Author | Karl Bordeau |
| Author | Morgan Michalet |
| Author | Aïcha Keskes |
| Author | Simon Valdenaire |
| Author | Pierre Debuire |
| Author | Marie Cantaloube |
| Author | Morgane Cabaillé |
| Author | Fabienne Portales |
| Author | Roxana Draghici |
| Author | Marc Ychou |
| Author | Eric Assenat |
| Author | Thibault Mazard |
| Author | Emmanuelle Samalin |
| Author | Ludovic Gauthier |
| Author | Pierre-Emmanuel Colombo |
| Author | François-Régis Souche |
| Author | Pascal Fenoglietto |
| Author | David Azria |
| Author | Olivier Riou |
| Abstract | Introduction: Stereotactic MR-guided Adaptive RadioTherapy (SMART) is a novel process to treat pancreatic tumors. We present an update of the data from our prospective registry of SMART for pancreatic tumors. Materials and methods: After the establishment of the SMART indication in a multidisciplinary board, we included all patients treated for pancreatic tumors. Primary endpoints were acute and late toxicities. Secondary endpoints were survival outcomes (local control, overall survival, distant metastasis free survival) and dosimetric advantages of adaptive process on targets volumes and OAR. Results: We included seventy consecutive patients in our cohort between October 2019 and April 2022. The prescribed dose was 50 Gy in 5 consecutive fractions. No severe acute SMART related toxicity was noted. Acute and late Grade ? 2 gastro intestinal were low. Daily adaptation significantly improved PTV and GTV coverage as well as OAR sparing. With a median follow-up of 10.8 months since SMART completion, the median OS, 6-months OS, and 1-year OS were 20.9 months, 86.7% (95% CI: (75?93%), and 68.6% (95% CI: (53?80%), respectively, from SMART completion. Local control at 6 months, 1 year, and 2 years were, respectively, 96.8 % (95% CI: 88?99%), 86.5 (95% CI: 68?95%), and 80.7% (95% CI: 59?92%). There was no grade > 2 late toxicities. Locally Advanced Pancreatic Cancers (LAPC) and Borderline Resectable Pancreatic Cancers (BRPC) patients (52 patients) had a median OS, 6-months OS, and 1-year OS from SMART completion of 15.2 months, 84.4% (95% CI: (70?92%)), and 60.5% (95% CI: (42?75%)), respectively. The median OS, 1-year OS, and 2-year OS from initiation of induction chemotherapy were 22.3 months, 91% (95% CI: (78?97%)), and 45.8% (95% CI: (27?63%)), respectively. Twenty patients underwent surgical resection (38.7 % of patients with initially LAPC) with negative margins (R0). Conclusion: To our knowledge, this is the largest series of SMART for pancreatic tumors. The treatment was well tolerated with only low-grade toxicities. Long-term OS and LC rates were achieved. SMART achieved high secondary resection rates in LAPC patients. |
| Publication | Cancers |
| Volume | 15 |
| Issue | 1 |
| Pages | 7 |
| Date | 2022-12-20 |
| Journal Abbr | Cancers (Basel) |
| Language | eng |
| DOI | 10.3390/cancers15010007 |
| ISSN | 2072-6694 |
| Short Title | Stereotactic MR-Guided Adaptive Radiotherapy for Pancreatic Tumors |
| Library Catalog | PubMed |
| Extra | Number: 1 PMID: 36612004 PMCID: PMC9817834 |
| Tags | borderline resectable pancreatic cancers (BRPC), clinic, first-last-coresponding, locally advanced pancreatic cancer (LAPC), pancreas cancer, pancreatic tumors, stereotactic body radiation therapy (SBRT), stereotactic MR-guided adaptive radio therapy (SMART) |
| Date Added | 2023/11/23 - 12:48:40 |
| Date Modified | 2024/12/15 - 03:57:49 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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