| Added by | mollevi |
|---|---|
| Last modified by | Nathalie Bonnefoy |
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells |
| Creator | Mombelli et al. |
| Author | S. Mombelli |
| Author | S. Cochaud |
| Author | Y. Merrouche |
| Author | C. Garbar |
| Author | F. Antonicelli |
| Author | E. Laprevotte |
| Author | G. Alberici |
| Author | N. Bonnefoy |
| Author | J. F. Eliaou |
| Author | J. Bastid |
| Author | A. Bensussan |
| Author | J. Giustiniani |
| Abstract | Pro-inflammatory IL-17 cytokines were initially described for their pathogenic role in chronic inflammatory diseases and subsequent accumulating evidence indicated their involvement in carcinogenesis. In the present study we report that IL-17A and IL-17E receptors subunits mRNA expressions are upregulated in breast cancers versus normal samples. IL-17E, which is undetectable in most normal breast tissues tested, seems more expressed in some tumors. Investigation of the molecular signaling following stimulation of human breast cancer cell lines with IL-17A and IL-17E showed that both cytokines induced the phosphorylation of c-RAF, ERK1/2 and p70 S6 Kinase were involved in the proliferation and survival of tumor cells. Accordingly, IL-17A and IL-17E promoted resistance to Docetaxel and failed to induce apoptosis as previously reported for IL-17E. Interestingly, we also revealed that both cytokines induced the generation of tumorogenic low molecular weight forms of cyclin E (LMW-E), which high levels correlated strongly with a poor survival in breast cancer patients. These results show for the first time some of the molecular pathways activated by IL-17A and IL-17E that may participate to their pro-oncogenic activity in breast cancers. |
| Publication | Sci Rep |
| Volume | 5 |
| Pages | 11874 |
| Date | 2015 |
| Journal Abbr | Scientific reports |
| DOI | 10.1038/srep11874 |
| ISSN | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Tags | original |
| Date Added | 2018/11/14 - 12:04:32 |
| Date Modified | 2019/05/28 - 21:23:32 |
| Notes and Attachments | (Note) (Note) 26154409 (Attachment) |
Institut de Recherche en Cancérologie de
