| Added by | Cavailles |
|---|---|
| Group name | EquipeVC |
| Item Type | Journal Article |
| Title | The Prognostic Impact of the Aryl Hydrocarbon Receptor (AhR) in Primary Breast Cancer Depends on the Lymph Node Status |
| Creator | Jeschke et al. |
| Author | Udo Jeschke |
| Author | Xi Zhang |
| Author | Christina Kuhn |
| Author | Stéphan Jalaguier |
| Author | Jacques Colinge |
| Author | Kristina Pfender |
| Author | Doris Mayr |
| Author | Nina Ditsch |
| Author | Nadia Harbeck |
| Author | Sven Mahner |
| Author | Sophie Sixou |
| Author | Vincent Cavaillès |
| Abstract | Increasing evidence implicates the aryl hydrocarbon receptor (AhR) as a possible regulator of mammary carcinogenesis. This study aims to clarify its prognostic impact in breast cancer (BC). Meta-analyses performed at the mRNA level demonstrated that the predictive value of AhR expression in BC depends on the lymph node (LN) status. AhR expression and sub-cellular location were then analyzed by immunohistochemistry in 302 primary BC samples. AhR was expressed in almost 90% of cases with a predominant nuclear location. Nuclear and cytoplasmic AhR levels were significantly correlated and associated with the expression of RIP140 (receptor-interacting protein of 140 kDa), an AhR transcriptional coregulator and target gene. Interestingly, total and nuclear AhR levels were only significantly correlated with short overall survival in node-negative patients. In this sub-group, total and nuclear AhR expression had an even stronger prognostic impact in patients with low RIP140-expressing tumors. Very interestingly, the total AhR prognostic value was also significant in luminal-like BCs and was an independent prognostic marker for LN-negative patients. Altogether, this study suggests that AhR is a marker of poor prognosis for patients with LN-negative luminal-like BCs, which warrants further evaluation. |
| Publication | International Journal of Molecular Sciences |
| Volume | 20 |
| Issue | 5 |
| Date | Feb 26, 2019 |
| Journal Abbr | Int J Mol Sci |
| Language | eng |
| DOI | 10.3390/ijms20051016 |
| ISSN | 1422-0067 |
| Library Catalog | PubMed |
| Extra | PMID: 30813617 PMCID: PMC6429124 |
| Tags | AhR, breast cancer, Breast Neoplasms, Female, Gene Expression Regulation, Neoplastic, Humans, last, luminal-like, lymph node, Lymph Nodes, Nuclear Receptor Interacting Protein 1, original, own, Prognosis, prognostic marker, Receptors, Aryl Hydrocarbon, RIP140, RNA, Messenger, Survival Analysis |
| Date Added | 2019/05/16 - 11:11:31 |
| Date Modified | 2023/11/21 - 14:22:30 |
| Notes and Attachments | PubMed entry (Attachment) PubMed entry (Attachment) Texte intégral (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
