| Added by | standudu |
|---|---|
| Last modified by | jacques.colinge |
| Group name | EquipeJC |
| Item Type | Journal Article |
| Title | Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma |
| Creator | Granier et al. |
| Author | Clémence Granier |
| Author | Charles Dariane |
| Author | Pierre Combe |
| Author | Virginie Verkarre |
| Author | Saïk Urien |
| Author | Cécile Badoual |
| Author | Hélène Roussel |
| Author | Marion Mandavit |
| Author | Patrice Ravel |
| Author | Mathilde Sibony |
| Author | Lucie Biard |
| Author | Camélia Radulescu |
| Author | Emeline Vinatier |
| Author | Nadine Benhamouda |
| Author | Michael Peyromaure |
| Author | Stéphane Oudard |
| Author | Arnaud Méjean |
| Author | Marc-Olivier Timsit |
| Author | Alain Gey |
| Author | Eric Tartour |
| Abstract | Inhibitory receptors expressed by T cells mediate tolerance to tumor antigens, with coexpression of these receptors exacerbating this dysfunctional state. Using the VectraR automated multiparametric immunofluorescence technique, we quantified intratumoral CD8+T cells coexpressing the inhibitory receptors PD-1 and Tim-3 from patients with renal cell carcinoma (RCC). A second validation cohort measured the same parameters by cytometry. The percentage of tumor-infiltrating CD8+T cells coexpressing PD-1 and Tim-3 correlated with an aggressive phenotype and a larger tumor size at diagnosis. Coexpression of PD-1 and Tim-3 above the median conferred a higher risk of relapse and a poorer 36-month overall survival. Notably, other CD8+T-cell subsets did not exert a similar effect on overall survival. Moreover, only the PD-1+Tim-3+subset of CD8+T cells exhibited impaired function after stimulation. Our findings establish intratumoral Tim-3+PD1+CD8+T cells as critical mediators of an aggressive phenotype in RCC. Use of the Vectra tool may be useful to identify similarly critical prognostic and predictive biomarkers in other tumor types and their response to immunotherapy.Cancer Res; 77(5); 1075-82. ©2016 AACR. |
| Publication | Cancer Research |
| Volume | 77 |
| Issue | 5 |
| Pages | 1075-1082 |
| Date | Mar 01, 2017 |
| Journal Abbr | Cancer Res. |
| Language | eng |
| DOI | 10.1158/0008-5472.CAN-16-0274 |
| ISSN | 1538-7445 |
| Library Catalog | PubMed |
| Extra | PMID: 27872087 |
| Tags | Carcinoma, Renal Cell, CD8-Positive T-Lymphocytes, Cohort Studies, Hepatitis A Virus Cellular Receptor 2, Humans, Immunophenotyping, Kidney Neoplasms, original, Programmed Cell Death 1 Receptor, Retrospective Studies, T-Lymphocyte Subsets |
| Date Added | 2018/02/28 - 16:51:51 |
| Date Modified | 2019/05/14 - 21:01:55 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
