| Added by | pcoopman |
|---|---|
| Group name | EquipePC |
| Item Type | Journal Article |
| Title | No Association of Early-Onset Breast or Ovarian Cancer with Early-Onset Cancer in Relatives in BRCA1 or BRCA2 Mutation Families |
| Creator | Imbert-Bouteille et al. |
| Author | Marion Imbert-Bouteille |
| Author | Carole Corsini |
| Author | Marie-Christine Picot |
| Author | Lucas Mizrahy |
| Author | Sandrine Akouete |
| Author | Helena Huguet |
| Author | Frédéric Thomas |
| Author | David Geneviève |
| Author | Patrice Taourel |
| Author | Marc Ychou |
| Author | Virginie Galibert |
| Author | Chloé Rideau |
| Author | Karen Baudry |
| Author | Tatiana Kogut Kubiak |
| Author | Isabelle Coupier |
| Author | Rémy Hobeika |
| Author | Yvette Macary |
| Author | Alain Toledano |
| Author | Jérôme Solassol |
| Author | Antoine Maalouf |
| Author | Jean-Pierre Daures |
| Author | Pascal Pujol |
| Abstract | According to clinical guidelines, the occurrence of very early-onset breast cancer (VEO-BC) (diagnosed ? age 30 years) or VEO ovarian cancer (VEO-OC) (diagnosed ? age 40 years) in families with BRCA1 or BRCA2 mutation (BRCAm) prompts advancing the age of risk-reducing strategies in relatives. This study aimed to assess the relation between the occurrence of VEO-BC or VEO-OC in families with BRCAm and age at BC or OC diagnosis in relatives. We conducted a retrospective multicenter study of 448 consecutive families with BRCAm from 2003 to 2018. Mean age and 5-year-span distribution of age at BC or OC in relatives were compared in families with or without VEO-BC or VEO-OC. Conditional probability calculation and Cochran-Mantel-Haenszel chi-square tests were used to investigate early-onset cancer occurrence in relatives of VEO-BC and VEO-OC cases. Overall, 15% (19/245) of families with BRCA1m and 9% (19/203) with BRCA2m featured at least one case of VEO-BC; 8% (37/245) and 2% (2/203) featured at least one case of VEO-OC, respectively. The cumulative prevalence of VEO-BC was 5.1% (95% CI 3.6-6.6) and 2.5% (95% CI 1.4-3.6) for families with BRCA1m and BRCA2m, respectively. The distribution of age and mean age at BC diagnosis in relatives did not differ by occurrence of VEO-BC for families with BRCA1m or BRCA2m. Conditional probability calculations did not show an increase of early-onset BC in VEO-BC families with BRCA1m or BRCA2m. Conversely, the probability of VEO-BC was not increased in families with early-onset BC. VEO-BC or VEO-OC occurrence may not be related to young age at BC or OC onset in relatives in families with BRCAm. This finding-together with a relatively high VEO-BC risk for women with BRCAm-advocates for MRI breast screening from age 25 regardless of family history. |
| Publication | Genes |
| Volume | 12 |
| Issue | 7 |
| Pages | 1100 |
| Date | 2021-07-20 |
| Journal Abbr | Genes (Basel) |
| Language | eng |
| DOI | 10.3390/genes12071100 |
| ISSN | 2073-4425 |
| Library Catalog | PubMed |
| Extra | PMID: 34356116 PMCID: PMC8305427 |
| Tags | Adult, Age of Onset, BRCA1, BRCA1 Protein, BRCA2, BRCA2 Protein, breast cancer, Breast Neoplasms, clinic, early-onset, Female, France, Genetic Predisposition to Disease, Humans, Middle Aged, Mutation, Ovarian Neoplasms, Retrospective Studies, Risk Factors, Young Adult |
| Date Added | 2022/07/29 - 18:23:08 |
| Date Modified | 2022/07/29 - 18:23:08 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
