| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Identification of a regulatory V?1 gamma delta T cell subpopulation expressing CD73 in human breast cancer |
| Creator | Chabab et al. |
| Author | Ghita Chabab |
| Author | Clément Barjon |
| Author | Naoill Abdellaoui |
| Author | Lucie Salvador-Prince |
| Author | Cécile Dejou |
| Author | Henri-Alexandre Michaud |
| Author | Florence Boissière-Michot |
| Author | Evelyne Lopez-Crapez |
| Author | William Jacot |
| Author | Didier Pourquier |
| Author | Nathalie Bonnefoy |
| Author | Virginie Lafont |
| Abstract | ?? T cells contribute to the immune response against many cancers, notably through their powerful effector functions that lead to the elimination of tumor cells and the recruitment of other immune cells. However, their presence in the tumor microenvironment has been associated with poor prognosis in breast, colon, and pancreatic cancer, suggesting that ?? T cells may also display pro-tumor activities. Here, we identified in blood from healthy donors a subpopulation of V?1T cells that represents around 20% of the whole V?1 population, expresses CD73, and displays immunosuppressive phenotype and functions (i.e., production of immunosuppressive molecules, such as IL-10, adenosine, and the chemotactic factor IL-8, and inhibition of ?? T cell proliferation). We then found that in human breast tumors, ?? T cells were present particularly in late stage breast cancer samples, and that ?20% of tumor-infiltrating ?? T cells expressed CD73. Taken together, these results suggest that regulatory ?? T cells are present in the breast cancer microenvironment and may display immunosuppressive functions through the production of immunosuppressive molecules, such as IL-10, IL-8, and adenosine, thus promoting tumor growth. |
| Publication | Journal of Leukocyte Biology |
| Volume | 107 |
| Issue | 6 |
| Pages | 1057-1067 |
| Date | 2020-06 |
| Journal Abbr | J Leukoc Biol |
| Language | eng |
| DOI | 10.1002/JLB.3MA0420-278RR |
| ISSN | 1938-3673 |
| Library Catalog | PubMed |
| Extra | PMID: 32362028 |
| Tags | 5'-Nucleotidase, Adolescent, Adult, Aged, Breast Neoplasms, Case-Control Studies, Cell Differentiation, Cell Lineage, clinic, Female, Gene Expression Regulation, Neoplastic, GPI-Linked Proteins, Humans, immunosuppression, Interleukin-10, Interleukin-8, Lymphocyte Activation, Lymphocytes, Tumor-Infiltrating, Middle Aged, non-conventional T cells, Primary Cell Culture, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Signal Transduction, T-Lymphocytes, Regulatory, Tumor Microenvironment |
| Date Added | 2023/11/14 - 15:21:24 |
| Date Modified | 2023/11/14 - 15:45:14 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
