| Added by | celine.gongora |
|---|---|
| Group name | EquipeCG |
| Item Type | Journal Article |
| Title | From old alkylating agents to new minor groove binders |
| Creator | Puyo et al. |
| Author | Stéphane Puyo |
| Author | Danièle Montaudon |
| Author | Philippe Pourquier |
| Abstract | Alkylating agents represent the oldest class of anticancer agents with the approval of mechloretamine by the FDA in 1949. Even though their clinical use is far beyond the use of new targeted therapies, they still occupy a major place in the treatment of specific malignancies, sometimes representing the unique option for the treatment of refractory tumors. Here, we are reviewing the major classes of alkylating agents, with a particular focus on the latest generations of compounds that specifically target the minor groove of the DNA. These naturally occurring derivatives have a unique mechanism of action that explains the recent regain of interest in developing new classes of alkylating agents that could be used in combination with other anticancer drugs to enhance tumor response in the clinic. |
| Publication | Critical Reviews in Oncology/Hematology |
| Volume | 89 |
| Issue | 1 |
| Pages | 43-61 |
| Date | Jan 2014 |
| Journal Abbr | Crit. Rev. Oncol. Hematol. |
| Language | eng |
| DOI | 10.1016/j.critrevonc.2013.07.006 |
| ISSN | 1879-0461 |
| Library Catalog | PubMed |
| Extra | PMID: 23972663 |
| Tags | Alkylating Agents, Alkylation, Animals, Antineoplastic Agents, Alkylating, DNA, DNA adducts, DNA crosslinks, Drug Resistance, Neoplasm, first, Humans, last, Neoplasms, O6-methylguanine, phd, review, Signal Transduction |
| Date Added | 2019/05/14 - 12:03:35 |
| Date Modified | 2019/10/24 - 17:31:28 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
