| Added by | mollevi |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Intravoxel incoherent motion diffusion-weighted imaging in the liver: comparison of mono-, bi- and tri-exponential modelling at 3.0-T |
| Creator | Cercueil et al. |
| Author | Jean-Pierre Cercueil |
| Author | Jean-Michel Petit |
| Author | Philippe Soyer |
| Author | Audrey Fohlen |
| Author | Marie-Ange Pierredon-Foulongne |
| Author | Valentina Schembri |
| Author | Elisabeth Delhom |
| Author | Sabine Schmidt |
| Author | Alban Denys |
| Author | Serge Aho |
| Author | Boris Guiu |
| Abstract | PURPOSE: To determine whether a mono-, bi- or tri-exponential model best fits the intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) signal of normal livers. MATERIALS AND METHODS: The pilot and validation studies were conducted in 38 and 36 patients with normal livers, respectively. The DWI sequence was performed using single-shot echoplanar imaging with 11 (pilot study) and 16 (validation study) b values. In each study, data from all patients were used to model the IVIM signal of normal liver. Diffusion coefficients (Di ± standard deviations) and their fractions (fi ± standard deviations) were determined from each model. The models were compared using the extra sum-of-squares test and information criteria. RESULTS: The tri-exponential model provided a better fit than both the bi- and mono-exponential models. The tri-exponential IVIM model determined three diffusion compartments: a slow (D1?=?1.35?±?0.03?×?10(-3) mm(2)/s; f1?=?72.7?±?0.9 %), a fast (D2?=?26.50?±?2.49?×?10(-3) mm(2)/s; f2?=?13.7?±?0.6 %) and a very fast (D3?=?404.00?±?43.7?×?10(-3) mm(2)/s; f3?=?13.5?±?0.8 %) diffusion compartment [results from the validation study]. The very fast compartment contributed to the IVIM signal only for b values ?15 s/mm(2) CONCLUSION: The tri-exponential model provided the best fit for IVIM signal decay in the liver over the 0-800 s/mm(2) range. In IVIM analysis of normal liver, a third very fast (pseudo)diffusion component might be relevant. KEY POINTS: ? For normal liver, tri-exponential IVIM model might be superior to bi-exponential ? A very fast compartment (D?=?404.00?±?43.7?×?10 (-3) mm (2) /s; f?=?13.5?±?0.8 %) is determined from the tri-exponential model ? The compartment contributes to the IVIM signal only for b???15 s/mm(2). |
| Publication | European Radiology |
| Volume | 25 |
| Issue | 6 |
| Pages | 1541-1550 |
| Date | Jun 2015 |
| Journal Abbr | Eur Radiol |
| Language | eng |
| DOI | 10.1007/s00330-014-3554-6 |
| ISSN | 1432-1084 |
| Short Title | Intravoxel incoherent motion diffusion-weighted imaging in the liver |
| Library Catalog | PubMed |
| Extra | PMID: 25527431 |
| Tags | Adult, Aged, Diffusion Magnetic Resonance Imaging, Echo-Planar Imaging, Female, Humans, Liver, Male, Middle Aged, Models, Theoretical, Motion, original, Pilot Projects, Prospective Studies, Reference Values, Reproducibility of Results, Young Adult |
| Date Added | 2018/11/13 - 17:35:18 |
| Date Modified | 2019/05/21 - 14:56:22 |
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