Research
Epitranscriptomics & Cancer Adaptation : A.David

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Our research work focuses on the contribution of post-transcriptional mechanisms on cancer cell adaptation, in particular RNA epigenetic & translational control.

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24 Items
Title  Creator  Group name  Publishing year 
Replication poison treated BRCA1-deficient breast cancers are prone to MRE11 over-resection resulting in single strand DNA accumulation and mitotic catastrophe. Tabet et al. EquipeCTCS 2025
E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development Di Michele et al. EquipeCTCS 2025-01-02
CDK inhibition results in pharmacologic BRCAness increasing sensitivity to olaparib in BRCA1-WT and olaparib resistant in Triple Negative Breast Cancer Orhan et al. EquipeCTCS 2024-05-01
BRCA1-methylated triple negative breast cancers previously exposed to neoadjuvant chemotherapy form RAD51 foci and respond poorly to olaparib Velazquez et al. EquipeMY 2023
RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation Guénolé et al. EquipeCTCS 2022-06-03
Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer Batnini et al. EquipeCTCS 2022-08-16
In high-grade ovarian carcinoma, platinum-sensitive tumor recurrence and acquired-resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and SOX2 du Manoir et al. EquipeCTCS 2022-07
Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy? Orhan et al. EquipeCTCS 2021-06-11
Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition Hayek et al. EquipeCTCS Jan 15, 2020
Distinct oncogenes drive different genome and epigenome alterations in human mammary epithelial cells Fonti et al. EquipeCTCS Sep 01, 2019
Coprs inactivation leads to a derepression of LINE1 transposons in spermatocytes Paul et al. EquipeAM Jan 2019
Cell-cycle regulation of non-enzymatic functions of the Drosophila methyltransferase PR-Set7 Zouaz et al. EquipeEJ Apr 06, 2018
Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication Brustel et al. EquipeCTCS 09 15, 2017
Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition Arnould et al. PlateformeRHEM 2017-11-10
E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis Goguet-Rubio et al. EquipeLL 09 27, 2016
E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity Lacroix et al. EquipeCTCS 09 27, 2016
The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion Paul et al. EquipeCTCS Feb 13, 2015
The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions Rodier et al. EquipeEJ Apr 14, 2015
Description of an optimized ChIP-seq analysis pipeline dedicated to genome wide identification of E4F1 binding sites in primary and transformed MEFs Houlès et al. EquipeCTCS Sep 2015
PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome Girardot et al. EquipeCTCS Jan 2014
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells Tardat et al. EquipeEJ Nov 2010
PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse Pannetier et al. EquipeEJ Oct 2008
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase Tardat et al. EquipeEJ Dec 31, 2007
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation Le Cam et al. EquipeEJ Nov 17, 2006
24 Items


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Located in the Parc Euromédecine, the Institut de Recherche en Cancérologie de Montpellier (U1194) is located on the Val d'Aurelle Campus (ICM, Institut régional du Cancer Montpellier/ Val d'Aurelle).

U1194 Research Centre supported by Inserm, the University of Montpellier and the Institut du Cancer de Montpellier (ICM)

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Montpellier (U1194) - Campus Val d'Aurelle

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