Associate professor of epidemiology, University of Montpellier & CHU Nîmes
PCCEI (UM, Inserm, EFS) research unit
Research head of the ExposUM Institute
Airborne transmission was an emblematic point of tension during the COVID pandemic. From its identification to its prevention, it represents both a scientific and a health issue. In this lecture, we will draw on recent reviews and key works in the literature, while situating older sources in the evolution of points of view on the subject, in an attempt to summarise the main historical, biophysical and epidemiological elements relating to airborne transmission, with an emphasis on the contributions of modelling to the study of this subject, now a public health priority.
Noted of, the scientific seminar will be followed by an institutional presentation of the ExposUM Institute.
host : Antonio MARAVER (IRCM)
Department Hematology and Medical Oncology, University Medical Center Mainz, Germany
host : Alexandre Djiane (IRCM)
Business Developer
ENSCM-USCBF-CN
host : Eric JULIEN (IRCM)
Institut de Génétique Humaine (IGH), CNRS UMR 9002
Université de Montpellier, France
Our research investigates the molecular mechanisms and functions of protein compartmentalization in response to DNA damage and repair. Focusing on two critical scaffolding proteins, TopBP1 and SLX4, we have elucidated how their assembly into nanocondensate clusters following DNA damage activates specific signalling pathways. Our research aims to demonstrate how DNA repair foci, functioning as biomolecular condensates, link molecular mechanisms to cellular physiological functions. Our work offers valuable insights into the regulatory mechanisms of the DNA damage response compartmentalization and opens new avenues for developing innovative cancer management strategies.
Institut de Génétique Moléculaire de Montpellier (IGMM) CNRS-UMR 5535
Route de Mende, Montpellier
Dr. Gregoire and his collaborators develop innovative murine models to study liver cancer heterogenity. They explore how the genetic composition of hepatocarcinoma influences their development, their interaction with the microenvironment, and their response to therapies.
Equipe "Génétique et développement des tumeurs cérébrales"
Institut du Cerveau / ICM
Hôpital de la Pitié-Salpêtrière
CNRS UMR7225-Inserm U1127-Sorbonne Université
contact : Lucille STUANI (IRCM)
Institut de Chimie des Milieux Matériaux de Poitiers (IC2MP)-ULR CNRS 7285
Professeur des Universités, Responsable de l'Equipe OrgaSynth
host : Eric Julien (IRCM)
Tokyo University (Japan)
host: Sophie Pattingre (IRCM)
Autophagy is an intracellular degradation system conserved in many eukaryotes. In the process of autophagy, a portion of the cytoplasm is surrounded by autophagosomes and then delivered to lysosomes for degradation. Studies on the molecular mechanism and physiological function of autophagy have made remarkable progress over the past 20 years since the landmark genetic studies in yeast by Dr. Ohsumi and other groups. In this seminar, I will summarize the current status of autophagy research, including methodology, and discuss some recent topics on autophagosome-lysosome fusion, selective degradation of mitochondria by autophagy, and the reversibility of cellular dysfunction caused by autophagy defects.